Metermine Side Effects: Understanding short-term and long-term consequences

Kathryn Bolton

Kathryn Bolton

APD, Anutr, Diabets, IBS

Kathryn Bolton is a dietitian practitioner. She helps people who care about their health and weight to eat better without saving on pleasure! She provides professional advice on healthy eating. The focus is on nutrition for people with diabetes, irritable bowel syndrome and other diseases. Bachelor’s degree from Queensland University of Technology (Nutrition and Dietetics), member of the Society for Australian Independent Dietitian-Nutritionists (AIDNSoc) and the Dietitians Association of Australia (DAA).
, reviewed by
– Updated March 23, 2022

Metermine, a popular anorectic drug, has proven effective for many individuals in their weight loss journey. However, it’s crucial to understand the potential side effects that may accompany its use. This article provides an in-depth exploration of the potential short-term and long-lasting side effects of Metermine, aiming to equip you with the knowledge needed to make informed decisions about your health.

Common side effects of Metrimine

Dry mouth or an unpleasant taste: This can occur at any dosage and is one of the most common side effects, reported by 73% of users in some studies. It usually starts within the first week of use and can last as long as the medication is taken.

Insomnia: Around 33% of users may experience difficulty sleeping, typically when starting the medication. This effect can be managed by taking Metermine early in the day.

Increased heart rate and high blood pressure: These are serious side effects that can occur at any dosage but are more common with higher doses. Regular monitoring is essential to prevent cardiovascular complications.

Gastrointestinal problems (diarrhea or constipation, nausea or vomiting): These effects can begin soon after starting the medication, affecting up to 30% of users. Increasing fluid and fiber intake can help manage these symptoms.

Nervousness or restlessness: Occurring in around 20% of users, these side effects can start within the first week of use and may persist as long as the medication is being taken.

Dizziness: About 20% of users report dizziness, often starting in the first week of use. If severe or persistent, medical advice should be sought.

Long-term side effects of Metrimine

Dependency or addiction: Metermine, like other drugs in its class, has potential for misuse, leading to physical or psychological dependency. Symptoms may include intense cravings, inability to stop or control use, and withdrawal symptoms upon cessation. The frequency is difficult to quantify as it greatly depends on individual factors.

Cardiovascular issues: Long-term use can contribute to sustained high blood pressure, increased heart rate, and other heart-related complications. These effects can occur at any dosage and are more common with higher doses or in individuals with pre-existing heart conditions. Regular monitoring is essential.

Mental health problems: Chronic use of Metermine can lead to mood swings, agitation, or depression. The frequency and severity of these effects can vary, but any changes in mood or behavior should be promptly reported to a healthcare provider.

Sexual dysfunction or changes in libido: Some users may experience decreased sexual desire or performance issues. These side effects are less common and their frequency is difficult to determine without specific studies.

Disturbed sleep patterns or chronic insomnia: Chronic insomnia can result from long-term use. Symptoms can persist even after stopping the medication and may require treatment.

Tolerance: Over time, your body may become used to the effects of Metermine, reducing its effectiveness. This can lead some users to increase their dosage, which is not recommended due to the increased risk of side effects.

Metermine 30 mg side effects

Like with any other prescription medicine, the side effects of Metermine could be barely noticeable or severe. However, it would be a mistake to ignore the correct dose, an aspect of treatment that is easy to neglect at first glance.

Metermine 30 mg may cause a variety of side effects that may cause a severe health emergency:

Acute cardiovascular illness
Myocardial infarction

The outcomes listed above are as improbable as a blizzard on Hawaii, but Nature lives its own way. If you ignore warnings and recommendations and fail to observe appropriate dose quantity, even such rare adverse reactions may suddenly become a reality.

People who take Metermine 30 mg, however, mention more common side effects, such as:

Increased heartbeat rate
Dry mouth
Mood swings
Digestion problems

Many people ask if there’s a critical difference between Duromine and Metermine. The difference between Metermine and Duromine is minimal when it comes to side effects.

Both may cause digestion irregularities and dryness of the mouth. If you experience any of the symptoms, contact a health care professional, and don’t forget to tell about the dose taken.

Metermine 40 mg side effects

The risk of side effects runs much higher when the concentration of the substance increases in your body. A dose of 40 mg may cause the following Metermine side effects:

Digestion irregularities
Increased heartbeat rate
Depressions and mood swings

If you commonly experience discomfort or it makes you feel uneasy, you might want to temporarily suspend treatment to give your body time to rest and recover.

It is important to remember that all decisions regarding Metermine intake must be made according to your doctor’s advice. Working with your healthcare provider, you can minimize Metermine side effects and lose weight safely.

Metermine and Alcohol

Always remember about the risks of alcohol consumption alongside any prescription drug! It’s always better to be safe than to face severe side effects.

Mixing Metermine and alcohol represents a serious threat to your life, not to mention side effects affecting your health. After all, like any other prescription drug that impacts your nervous system, Metermine mixed with alcohol will undoubtedly lead to adverse reactions.

When it comes to risks of alcohol consumption alongside your prescribed medicine, there is no difference between Metermine and Duromine. Both feature a strict warning sign related to alcohol consumption during the treatment. If you ignore the rules, it may lead to:

Increased heartbeat rate
Dry mouth

Anyone who wants to lose weight safely and fast should consistently follow the manufacturer’s recommendations. Note that alcohol is rich in calories and causes liquid retention. Avoid drinking alcohol, at least when you lose weight, and you will surely achieve better results.

Besides, you are the only one who can truly take responsibility for your own health. Therefore, stay consistent in your goals, and a perfect body will undoubtedly be yours.


While Metermine can be an effective tool for weight loss, it is important to weigh its benefits against potential side effects. These can range from common, less severe issues such as dry mouth and insomnia, to more serious long-term effects, including cardiovascular issues or psychological changes. Always consult with a healthcare provider to understand the full safety profile of Metermine before initiating therapy, and monitor your health closely while using this medication.


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