Difference between Duromine and Phentermine

Teresa Hong

Teresa Hong


Teresa Hong is a dietician who is actively engaged in food education. Develops nutritional methods available to as many people as possible. Offers specific dietary modification tools for people with endocrine disorders, food allergies, atherosclerosis, malnutrition, irritable bowel syndrome and other diseases. She will help to get rid of stress and enjoy every meal again!

, reviewed by
– Updated January 3, 2022

People often ask about the difference between Phentermine and Duromine and which one is better for weight loss. Duromine capsules and Phentermine tablets both work as appetite suppressants and have the same key component. It might seem that it is senseless to compare two anorectic drugs, which contain the same active component. However, let’s dig into the main differences these pills have.

Duromine vs Phentermine: Effects

Duromine contains the active ingredient Phentermine. It is logical that the appetite suppressant effect, provided by Duromine capsules and Phentermine pills, is the same. However, the pharmaceutical forms of these anorectics determine the release rate of the active ingredient, which is extended in Duromine capsules and is immediate in Phentermine pills.

In addition to appetite suppression, Phentermine, same as Duromine, provides a thermogenic effect, which means that they make your body produce more energy from the fat cells. This promotes the breakdown of the stored fat and boosts the weight loss results.

Duromine vs Phentermine: Dosage form and presentation

The difference between Duromine and Phentermine medications that we notice in the first place is their presentation. Duromine is produced in the form of capsules, while Phentermine 37.5 mg (most frequently prescribed dosage) comes in the form of tablets. Both forms have their advantages and disadvantages.

Duromine capsules by iNovaPhentermine HCl 37.5 mg pills by Teva
βœ“ Are easier to swallow. βœ“ May not dissolve in the stomach completely
βœ“ Duromine capsules are available in the dose of 15 mg, 30 mg, 40 mg; they should not be open or chewed. It cannot be divided or crushed. βœ“ Phentermine HCl 37.5 mg pills come in a single dose (equal to 30 mg Phentermine base), which can be split. However, you can also find different types of phentermine.
βœ“ 15 mg capsules are grey and green; 30 mg capsules are grey and reddish-brown; 40 mg capsules are grey and orange. βœ“ White tablets with blue specks, capsule-
shaped, with a groove in the midline.
Consumer Duromine Information PDFPhentermine Hydrochlorid leaflet PDF

Duromine vs Phentermine: Ingredients and action duration

Is Phentermine the same as Duromine? The main ingredient that provides the anorectic effect in both drugs is the Phentermine substance. So, what is this active ingredient? It is a substance that stimulates the central nervous system. The TGA approved Phentermine as a hunger-suppressing agent.

So, are phentermine and Duromine the same thing?

When comparing phentermine-based drugs produced by Teva and INova Pharmaceuticals, it is also important to take a closer look at the inactive components of these anorectics. This is due to the fact that they play a significant role in the onset and duration of the therapeutic effect provided.

While appetite suppression is the main action of both Duromine and Phentermine, its onset and duration are conditioned by the excipients used in these medicines:

βœ“ Duromine as Ion-exchange resin

Ion exchange resin is a polymeric material that, when interacting with the base (Phentermine), helps control the release of the drug and allows extending it up to several hours. Due to this, Phentermine is slowly released from the capsule* and absorbed into the bloodstream evenly during the day, which ensures long-lasting appetite suppression.

βœ“ Phentermine as Hydrochloride

Hydrochloride is an acid salt obtained when hydrochloric acid interacts with a base (Phentermine). This chemical reaction has been used for a long time in the pharmacological industry to help turn organic commands into water-soluble acid salts. Thus, the excipient facilitates the dissolution of Phentermine tablets in the gastrointestinal tract.

To sum up, Duromine capsules provide a slow and steady flux of the anorectic into the body. In contrast, Phentermine pills provide the maximum drug concentration when the pill dissolves and a gradual weakening of the anorexigenic effect during the day.

Duromine as Ion-exchange resin Phentermine as Hydrochloride
βœ“ Slow-release of the active substance βœ“ Fast, one-time release of the active substance
βœ“ Long-lasting equal appetite suppression throughout the day βœ“ Appetite suppression gradually subsides during the day
βœ“ Lower risk of severe side effects, because the dose of the drug enters the bloodstream in small even portions* βœ“ Higher risk of severe side effects, because the entire dose gets into the bloodstream at once
*film coating of Duromine capsules further ensures a slower release rate of the active ingredient

Duromine vs Phentermine: How to get

Since both medicines are potent CNS stimulants with a long list of possible side effects and contraindications and refer to the list of Controlled Substances, their purchase requires a prescription. Candidates that suit the criteria for Duromine/Phentermine prescription are obese people with a BMI higher than 30 kg/m2 or those whose BMI is higher than 27 kg/m2 and suffering from such risk factors like:

βœ• increased lipids level,
βœ• moderately high and controlled blood pressure,
βœ• diabetes.

If you are interested in getting Duromine

(Phentermine), please follow

Duromine vs Phentermine: Dosing regimen

Usual instructions for the administration schedule of Phentermine-containing medicines include:

βœ“ Take one Phentermine pill / Duromine capsule as early in the morning, as possible, with or without a meal.

βœ“ Avoid administration of the appetite suppressant in the second part of the day.

Both recommendations aim mainly the possibility of reducing the risk of insomnia, which is a common side effect of both Duromine and Phentermine. At that, people themselves need to figure out what is their own perfect time to take the drug.

Duromine vs Phentermine: Course duration

Even though the efficacy of Duromine and Phentermine is a well-proven thing, its high risk for adverse reactions does not allow using the drug for a long time, so the most extended duration of these drugs use is 12 weeks in a row. At that, the health of people, who take them, should be carefully monitored by the prescribing physician to avoid or timely β€œcatch” any health deterioration.

Duromine vs Phentermine: Contraindications

Since both drugs have the same active ingredient, contraindications to their adverse reactions are identical. It is critical that every person planning on taking Duromine or Phentermine gets familiarized with the list of contraindications and informs his doctor if he has any of the mentioned conditions or takes any of the said drugs.

Duromine vs Phentermine: Adverse reactions

This is one more similarity between Duromine capsules and Phentermine. Adverse reactions of Phentermine, the same as Duromine, can differ significantly from person to person. Some people report no side effects, while in other people, they get so severe that they have to stop using the drug. Before you begin taking any of these anorectics, learn the list of side effects and memorize those that require urgent medical assistance.

The most commonly reported side effects are:

βœ• xerostomia (dry mouth)
βœ• insomnia
βœ• headaches
βœ• dizziness
βœ• nausea
βœ• constipation

Phentermine GH

Phentermine GH is another Phentermine-containing medicine prescribed by doctors to patients who want to lose weight. 

The drug is released in capsules, which contain a combination of Phentermine and a resin with a slow-release action. 

You can find Phentermine GH 15 mg, Phentermine GH30 mg, and Phentermine GH 40 mg on the market. The mechanism of action is absolutely the same as the one in Duromine. As this is a slow-release drug, you should never split the capsules. Try to take it early in the morning. It will guarantee the effectiveness of the drug during the entire day.

Phentermine Juno ER

Phentermine Juno ER is the most popular Phentermine brand in Australia. It is produced by Australian Company Juno PC Holdings Pty Ltd. And has the same dosage as Duromine: 15 mg, 30 mg, and 40 mg tablets.

When comparing Phentermine Juno ER vs Duromine, it’s important to notice that Phentermine Juno ER has the following properties:

βœ“ is in tablets, not in capsules
βœ“ is free from lactose
βœ“ is gluten-free
βœ“ doesn’t contain gelatin or animal products
βœ“ has no reliance on gut ionic strength and pH
βœ“ environmentally friendly

We should notice that Phentermine Juno ER is a new generation of well-known Phentermine. It also has essential differences from traditional Phentermine.

PhenterminePhentermine Juno ER
Capsules containing polystyrene resin phentermine complex.Tablets patented Hydrophobic and Hydrophilic matrix formula.
Traditional Phentermine contains several tiny polystyrene resin beads bound to Phentermine.It is the only non-polystyrene resin formula in Australia. It is a mix of hydrophobic and hydrophilic ingredients forming a factual matrix.
Phentermine uses the exact ionic exchange mechanism to release Phentermine when the capsule breaks down in the gastrointestinal tract.Body temperature and gastric fluids release medication.
Polystyrene resin is not digestible and excretes into wastewater and the environment.Phentermine Juno ER  has no microplastics and is environmentally friendly.


So, is Phentermine and Duromine the same thing? 

Concluding all the above about Phentermine vs Duromine, let’s point the main similarities and differences:

βœ“ Duromine and Phentermine have the same active ingredient
βœ“ Both appetite suppressants have common effects on your body and brain
βœ“ There are different types of Duromine: 15 mg, 30 mg, and 40 mg. While Phentermine is classified by: 37.5 mg, 15 mg, 30 mg. 
βœ“ Duromine and Phentermine have different forms and presentation
βœ“ Both Duromine and Phentermine have pretty the same adverse reactions and contradictions.

It is worth mentioning that long-term use or increase in the dose of these anorectics for the sake of getting more energy is fraught with serious health deterioration and severe adverse events. If you think you took too much of either Duromine or Phentermine, you need to seek medical help immediately.

Keep in mind

You will get the best beneficial Duromine/Phentermine effects if you use the drugs alongside an efficient weight loss program (nutrition + activity + water + elimination of bad habits). It is essential to understand that not a single Phentermine-based medicine is capable of ensuring a significant, sustainable, or fast weight loss when used alone without complying with all measurements mentioned above.


8 thoughts on “Difference between Duromine and Phentermine”
  1. Just putting in my two cents. I had the opposite experience, Phentermine worked better for me and the side effects were more manageable. Different strokes for different folks, I guess

    • That’s exactly right, Lukas! πŸ‘ Both Duromine and Phentermine are designed to aid in weight loss, but everyone’s body responds differently to medications. It’s all about finding what works best for your individual needs, while also taking into account the potential side effects. Always remember to consult with your healthcare provider before making any changes to your medication regimen.

  2. I tried both Phentermine and Duromine. For me, Duromine worked best. The slow-release really helped curb my appetite for longer. Plus, I didn’t experience any severe side effects.

    • Hi @Jacinta567, it’s best to consult with your doctor before making any changes to your medication. They can provide guidance based on your personal health profile and treatment progress.

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